Antioxidant and antitumor activity of chloroform extract of Alangium salvifolium flowers

The present study was designed to investigate the antioxidant and antitumor activities of Alangium salviifolium (AS) wang flowers. Antioxidant potential of the AS extract was evaluated in vitro by DPPH (1,1diphenyl-2-picrylhydrazyl) scavenging assay and reducing power assay method. AS extract showed scavengin-g activity in all the methods with IC50 value of 182.31 ± 0.31 μg/ml for DPPH assay method. In reducing power assay, AS extract also showed significant (p0.001) activity. In addition, total phenolic and total antioxidant capacity were also determined. The antitumor effect of the flowers of AS against Ehrlich ascites carcinoma (EAC) in mice at the doses of 10 mg/kg body weight intraperitoneally. Significant (p0.001) increases of survival times 32.4 ± 0.77 days for chloroform extract of the (10 mg/kg) treated tumor bearing mice were confirmed with respect to the control group (22 ± 0.12 days). From the result it was showed that the extract has significant antioxidant as well as antitumor activity.